ГЭТ 208-2024 (НИО 243)
Standard name:
- ГЭТ 208-2024 State primary standard of units of mass (molar) fraction and mass (molar) concentration of organic components in liquid and solid substances and materials based on liquid and gas chromatography-mass spectrometry with isotope dilution and gravimetry
Type of measurement:
- Physicochemical measurements of the composition and properties of substances
Structural division: name НИО\НИЛ:
- Research Department of State Standards in the Field of Organic and Inorganic Analysis
Guardian Scientist:
- Candidate of Chemical Sciences Alena Yuryevna Mikheeva
Year of creation:
- 2014 г.
Year of re-confirmation:
- 2024 г. (приказ Росстандарта от 01.02.2024 № 264)
Operating principle:
In organic analysis, traceability to the SI is based on pure organic substances characterized at the highest analytical and metrological level. The mass fraction of the main component in the pure substance ensures traceability to one of the basic SI units—the amount of substance (mole). Thus, the first link in the formation of the metrological traceability chain in organic analysis is the determination of the substance's purity.
ГЭТ 208-2024 Implements the generally accepted international approach to determining the purity of organic substances—the mass balance method, based on the formula "100% minus the sum of impurities." This involves measuring four groups of probable impurity components in pure organic substances:
- Impurities of related compounds (generally, these are components that can be measured by the same analytical method as the main substance, most often its isomers and/or congeners);
- Impurities of water (free and crystalline hydrate);
- Impurities of volatile organic compounds (e.g., residual organic solvents after purification of the main substance by recrystallization);
- Impurities of non-volatile compounds, including organic and inorganic components (e.g., metals in any form).
The material carrier and means of transferring the unit of mole of an organic component are standard samples (SS) of the composition of pure organic substances and/or solutions of pure organic substances.
Composition of the standard:
Analytical complex Хд 1.456.497
- А 1 Gas chromatography/mass spectrometry based system (ГХ-МС) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.017;
- А 2 High performance liquid chromatography/mass spectrometry based system (ВЭЖХ-МС) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.018;
- А 3 Installation based on gas chromatography method (ГХ) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.019;
- А 4 Installation based on the high-performance liquid chromatography method (ВЭЖХ) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.020;
- А 5 Installation based on the method of mass spectrometry with ionization in inductively coupled plasma (ИСП-МС/МС) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.021;
- А 6 A setup based on the Karl Fischer coulometric titration method for measuring the mass fraction of water in pure substances Хд 2.840.022;
- А 7 Installation based ПЦР-РВ for measuring the mass fraction (concentration) of organic macromolecules Хд 2.840.023;
- А 8 Installation based on the method of thermogravimetry and synchronous thermal analysis (ТГА/СТА) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.024;
- А 9 High-resolution liquid chromatography/mass spectrometry system(ВЭЖХ-МС/ВР) for measuring the mass (molar) fraction (concentration) of components in pure substances, solutions and materials Хд 2.840.034
Gravimetric complex Хд 1.456.498 - А 10 Gravimetric installation for measuring the mass of pure substances, impurities of pure substances, solutions and materials Хд 2.840.025
ГЭТ 208-2024 The standard is based on universal analytical instruments commercially available on both domestic and international markets. The uniqueness of the standard complex lies not in its instrumentation, but in the analytical and metrological technologies and procedures developed, incorporated into ГЭТ 208-2024 as reference documentation, which enable the highest levels of measurement accuracy in organic analysis. Furthermore, a key component ensuring the successful operation of the standard is a staff of highly qualified specialists possessing analytical and metrological knowledge, skills, and experience.
Main metrological characteristics
| Name of units of measurement | Measurement range | Relative expanded uncertainty (at k=2) |
|---|---|---|
| Mass (molar) fraction of the main component in pure substances | from 0.80 g/g to 1.00 g/g (from 80.00% to 100.00%); |
from 3.0% to 0.01% |
| Mass fraction of components in solutions | 0.5•10-9 g/g to 0.5 g/g (from 0.5•10-7 % to 50%) |
from 5.0% to 0.01% |
| Mass concentration of components in solutions and molar concentration of components in solutions | from 1.0•10-5 to 100 g/dm3 from 0.3•10-8 to 2.5 mol/dm3 |
from 3.0% to 1.0% |
| Mass fraction of components in materials | 0.4•10-12 g/g to 0.99 g/g (from 1.0•10-10 % to 99%) |
from 12.0% to 0.01% |
| Mass concentration of components in materials and molar concentration of components in materials | from 1.0•10-5 to 100 g/dm3 from 0.3•10-8 to 2.5 mol/dm3 |
from 3.0% to 1.0% |
Verification diagram:
- State verification scheme for measuring instruments for the content of organic components in liquid and solid substances and materials (Order of Rosstandart dated 28.12.2024 No. 3158; Order of Rosstandart dated 14.02.2025 No. 302)
Scope of application:
Industry (chemical, food, pharmaceutical, light, automotive, etc.), agriculture, mechanical engineering, construction, transport, nuclear energy, military-industrial complex, healthcare, science, natural resources, etc.
Food quality and safety, quality of active pharmaceutical ingredients and finished medicinal products, clinical diagnostics, anti-doping control, production control of raw materials, technological processes and finished products, safety of building materials, occupational safety, environmental control and monitoring, etc.
Verification and calibration of measuring instruments, testing of standard samples for the purpose of type approval and serial production.
Results of applying the standard:
Using the standard, CRMs for the composition of pure organic substances and solutions were produced and sold: in 2024 - more than 1800 units, in 2025 - more than 2300 units.
The total number of measuring instruments traceable to ГЭТ 208-2024:
The total number of approved standard samples (ASS) traceable to the standard is more than 350 types.
Ensuring the uniformity of measurements, participation in the CIPM MRA program:
97
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